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Piepponen 1992 found the two treatments to be of comparable efficacy (SMD 0.03, 95% CI -0.36 to 0.42) (Analysis 2.6).
Another systematic review (Kastarinen 2011), which compared steroids versus azoles (mainly ketoconazole) for different treatment outcomes with seborrhoeic dermatitis, found steroids and ketoconazole to be of comparable efficacy.
A phase III trial showed the oral formulation to be of comparable efficacy to injected pentamidine; however, an extended phase I safety trial using 14 day dosing (instead of the successful 10 day dosing in the phase III trial) demonstrated unacceptable nephrotoxicity and development was halted.
In randomized controlled trials, PST has been shown to be of comparable efficacy to antidepressant medication in the treatment of major depression when delivered by experienced general practitioners [ 37], and in the treatment of dysthymia (though not minor depression) in adults aged 18 59 when delivered by psychologists with PhDs [ 38].
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"That was a Cochrane review, independent of everything else, concluding that Avastin is of comparable efficacy and safety.
In order for a new regimen to be licensed, it will be necessary to demonstrate that it is of comparable efficacy to the standard regimen.
It has been demonstrated that first-line regimens combining fluoropyrimidines with oxaliplatin or irinotecan are of comparable efficacy [ 15, 16].
It must be noted that the 6-week regimen of itraconazole is of comparable efficacy to griseofulvin, in cases of Microsporum-TC.
They are of comparable efficacy to the Mayo regime but with less toxicity (Carmichael et al, 2002; Douillard et al, 2002; Twelves et al, 2005).
Some researchers have claimed [ 8] that atypicals are of comparable efficacy to typical antipsychotics of medium or low potency, because lower-potency antipsychotics have a more favorable EPS profile, and thus provide greater tolerability and better outcomes.
It is very unlikely better results can be achieved with new drugs, a clinically more relevant goal would be a regimen of comparable efficacy to standard treatment but of substantially shorter duration.
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CEO of Professional Science Editing for Scientists @ prosciediting.com