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We performed the meta-analyses including selectively the studies involving consecutive patients, supposed to be of better methodological quality, and found, rather unexpectedly, that the relation between survival and markers of angiogenesis was not improved for RFS, and even deteriorated for OS.
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The Levels of Evidence Rating System causes readers to infer that Level I evidence RCTs are of better methodological quality than Level II evidence RCTs [ 8].
Therapeutic hypothermia for TBI has been subject to a number of trials of varying size and quality, however, some more recent trials, such as Marion [ 25] and Clifton [ 29], have been of better methodological quality.
This sensitivity analysis did not change the results much, e.g. the median quality score was 5 for meta-analyses with non-profit or no support and 2 for industry-supported meta-analyses (P < 0.01) We found that meta-analyses with non-profit or no support are of better methodological quality on average than those with industry support.
10 A higher score on the D&B scale is indicative of better methodological quality.
Limiting the findings to studies of better methodological quality is a notable strength that builds on past results [ 9, 10].
Sensitivity analysis (not shown) —When we restricted the analysis to trials of better methodological quality (that is, adequate methods of randomisation and allocation concealment) there was no change in results for clinical failure (n=105) 71722 or microbiological failure (n=45).
Further research of better methodological quality and with more patient-relevant outcomes is needed".
The presence of a stronger association with KS as compared to OQS suggests that the use of a structured RQ could be associated with better methodological quality.
Clinicians should become more engaged in research and be provided with better methodological training.
These databases are sources of systematic reviews that tend to be of higher methodological quality, which may reflect better reporting and hence better indexing.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com