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In the BZLF1 promoter, the elements are situated with 12 base pairs between the central nucleotides; both can be occupied simultaneously and both are functionally relevant [17], [19] [20].
However, all the mapped positions cannot be occupied simultaneously and may be mutually exclusive.
This improved the quality of available cavities but retained their total number (due to territoriality, sites in the same tree could not be occupied simultaneously) and location on the landscape.
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The crystallographic study by Kaskel identifies eight CD4 sites, four primary and four secondary sites, although not all can be occupied simultaneously due to the close proximity of some sites.
For instance, the promoter of the gene encoding for corticotropin releasing hormone (CRH) contains three glucocorticoid response elements but only two of the sites can be occupied simultaneously by a glucocorticoid nuclear receptor dimmer, with site occupancy depending on other transcription factors.
Our motif-liganded structure suggests that both motif-binding sites could be occupied simultaneously.
We reasoned that longer flexible spacers would enable all three binding pockets to be occupied simultaneously by one molecule.
Between March 2005 and August 2006 New Zealand became the only country in the world in which all the highest offices in the land (Head of State, Governor-General, Prime Minister, Speaker and Chief Justice) were occupied simultaneously by women.
It is only the second time both shuttle pads at Kennedy Space Center have been occupied simultaneously.
Not all of the castles were occupied simultaneously.
Using binding and flux experiments we had shown that the primary binding site (S1 site) and the S2 site could be occupied by substrate simultaneously, and that substrate in the extracellular vestibule S2 site could allosterically trigger intracellular release of Na+ and substrate from the S1 site, thereby functioning as a "symport effector" [29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com