Similar clustering of the samples was obtained using alternative methods (PCA of expression intensities and hierarchical clustering of expression calls; Figures S1B and S2B in Additional file 1).
We acknowledge that there is no established definition of what constitutes clinically significant insulin resistance, in particular for the young age-group studied; however, similar results were obtained using alternative definitions to signify the highest extent of insulin resistance.
Similar results to those presented here (not shown) are obtained using alternative measures of the STA magnitude, such as the area under its envelope (cf. phase analysis), or the maximum of its absolute value.
The same results were obtained using alternative implementations of ML ancestral reconstruction in R the ace function in the ape package (plotted as pie graphs in fig. 1 C) and pml functions in the phangorn package.
Similar results were obtained using alternative regression models in which confounders were determined using a forward selection approach, except for the association between prenatal Hg exposure (third tertile) and ADHD Hyperactive-impulsive type, which wADHD Hyperactive-impulsivetypelly significant [see Supplemental Material, Table S2 (http://dx.doi.org/10.1289/ehp.1204976)].
Similar results as those shown here are obtained using alternative measures of LFP strength, including the mean value of the envelope of the beta-filtered signal (cf. phase analysis) or by using the total signal power in the beta range (10 22 Hz).
In our study, not based on different scoring thresholds but rather on an extension of the number and type of PANSS items considered, a significant reduction of remission rates was obtained using alternative criteria, but which was not so marked as to be unrealistic.
Analysis of OmpA folding into octyl maltoside micelles showed that, although OmpA folding remained irreversible when urea was used as a denaturant, reversibility could be obtained using GuHCl as an alternative denaturant [156].
This work demonstrates that a measure of photocatalyst activity of self-cleaning glass, i.e. the time taken to change the colour of an Rz photocatalyst indicator ink, can be obtained using inexpensive digital photography, as alternative to more expensive lab-based techniques, such as UV vis spectrophotometry.
Numerical results show that promising design alternatives can be obtained using the proposed method.
