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During sunitinib treatment, responding RCC lesions can be observed with dramatic decrease in attenuation, but little change in size.
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A dramatic effect was observed with CG9430.
A slightly more dramatic effect was observed with pThr supplementation.
The results shown in Fig. 3A and B clearly indicate that all the single mutations except E273A reduce protein DNA binding affinity; a dramatic effect is observed with the ZF3 mutants in position +2 (hZFP57zf3-4S244A), +3 (hZFP57zf3-4G245andand +6 (hZFP57zf3-4R248andand the ZF 4 mutant in position +6 (hZFP57zf3-4R276A).
Another dramatic change that is observed with increasing annealing temperature is a reduction in the energy shift between 4 and 300 K, ΔEg (4 300 K), 129 meV for unannealed nanowires to 32.4 meV for the samples annealed at 750 °C as shown in Fig. 3b.
Although less dramatic, similar results were observed with PAR6 or PATJ knockdown.
In the TLC P/PEblend at 190 °C and 230 °C, dramatic reductions in viscosity were observed with significant improvement in extrudate surface smoothness and an enlarged processing window.
The most dramatic change of expression was observed with genes coding membrane transport proteins and genes related to metabolism.
In accordance with the mRNA destabilisation data, a dramatic PAI-1 repression was observed with both miRNAs, either individually or in combination.
A dramatic decrease in tumor vasculature was observed with M867 and radiation using von Willebrand factor staining.
Dramatic changes in endothelial function were observed with administration of miglitol.
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