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Collectively, our results indicated that the sensitization mechanism observed when Sal is combined with MK-2206 can be observed when combined with other Akt inhibitors.
This suggests that, although such inhibitors may be cytotoxic as single agents, increased therapeutic benefit may not be observed when combined with platinum drugs in tumours that do not exhibit increased Jak/Stat signalling.
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In addition, a stronger positive correlation was observed when combined preS2- and S-specific IFN-γ-secreting T cell responses were analyzed (r = 0.92, p<0.01).
A decrease in omeprazole (28%) and simvastatin (57%) exposure was observed when combined with tocilizumab.
In addition, dose-limiting pulmonary toxicity has been observed when combined with other chemotherapies.
Apparent panobinostat exposure AE and exposure ORR relationships were observed when combined with bortezomib and dexamethasone in the treatment of patients with relapsed and refractory multiple myeloma.
A significantly greater anti-proliferative (P=0.020, P=0.030), anti-angiogenic (P=0.040, P<0.0001) and pro-apoptotic (P=0.0083, P=0.0149) response was observed when combined treatment was compared with single gossypol/TMZ treatment response, respectively.
Two regions are observed when combining the LEISS and XPS data in situ.
The greatest efficiency gains were observed when combining this modification and replacing the flash evaporation throttling valve with a two-phase expander.
A weak trend in the same direction was observed when combining 3 independent external glioblastoma datasets.
The most striking therapeutic effect was observed when combining the three siRNAs targeting IL-1β/IL-6/IL-18 IL-1β/IL-6/IL-18 IL-1β/IL-6/IL-18 IL-1β/IL-6/IL-18
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