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This study highlights the large amount of repeat variation that can be observed using sequence traces.
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Furthermore, it is possible that the increase in nAG immunoreactivity observed by Kumar et al [ 34] is regulated at the level of translation and would not be observed using microarray or sequencing approaches.
Since the conversion can be observed using gibbon as the outgroup sequence, we conclude that it occurred after the separation of hominids from other apes.
Such difference cannot be observed using CNAG.
Previously, similar copy number differences were observed using Illumina sequence reads and were successfully validated for the nuwts in B. malayi[ 32].
A similar trend was observed using the sequence conservation or the GMS method, although differences between the categories of UV carriers were smaller.
Similar results were observed using 5' leader sequences based on the β-globin 5' leader, which contains more secondary structure than CAA repeats [23].
A "Neolithic" pattern also was observed using the (Finnish) sequences in non-Finn-characteristic haplogroups.
The 3′ region of the intron also possessed putative Sp1 binding sites (oligo-6); however, no transcription factor binding to this sequence was observed using the same method (data not shown).
In contrast, no developmental improvement in sequencing was observed using the frequency weighted measure (Table S3), which effectively de-emphasizes infrequently occurring syllables (see Methods).
Similar results were observed using multiple enzymatic digestion to enhance sequence coverage of proteins in human cerebrospinal fluid and ErbB2 tumor receptor.
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