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We along with others have previously shown that methylation of multiple tumor suppressor genes can be observed in bladder cancer patients as well as its corresponding voided urine samples [ 11- 15].
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Significant overexpression of UHRF1 was observed in bladder cancer.
NSD1 mutation/deletion is observed in bladder cancer.
This was observed in bladder carcinoma cell lines expressing either E- or N-cadherin.
Interestingly, methylene blue was observed in bladder lasting more than 48 hours.
A wide range of EMT scores was observed in bladder, breast, gastric, lung, ovarian and prostate cancers.
The pro-tumor effect of Id4 is observed in bladder [ 38] and rat mammary gland carcinomas [ 39].
Hypermethylation was observed in bladder cancer cells and associated with lack of gene expression, being restored in vitro by a demethylating agent.
Lower transcript levels of KiSS-1 were observed in bladder carcinomas, as compared to superficial tumours, and these ratios provided prognostic information.
The gain of a large fragment of 8q also known as an isochrome 8q has been observed in bladder cancer (Sauter et al, 1995).
Furthermore, a relatively high frequency of methylation CCNA1 gene was observed in bladder cancer tissues but not in normal uroepithelium, revealing that CCNA1 gene promoter methylation may participate in the pathogenesis of bladder cancer [ 5].
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CEO of Professional Science Editing for Scientists @ prosciediting.com