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The digestive forms, megaesophagus or megacolon may be observed in advanced stages of the disease [ 3].
In fact, elevated levels of the subfamily of extracellular signal-regulated kinases 1 and 2 (ERK-1/2) could be observed in advanced prostate tumours (Gioeli et al, 1999; Price et al, 1999; Uzgare et al, 2003).
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Increased Pak1 activity has been observed in advanced stages of breast, brain, pancreatic, ovarian, and colon cancers [1].
Increases in MAPK activity have been observed in advanced PCa suggesting that a constitutively active Ras pathway might be associated with prostate cancer progression and metastasis [7], [24].
Highest expression levels are observed in advanced metastatic disease.
No significant difference was observed in advanced stage CRC patients (Stage IV).
Moreover, a higher antigen presenting capacity was observed in advanced cancer patients compared to normal controls.
Moreover, moderately decreased ASNS expression was observed in advanced cancer in comparison with early cancer in human HCC clinical specimens.
92 Similarly, expression of claudin-3 and -4 was observed in advanced ovarian cancer but not in ovarian cystadenomas.
Loss of p21 has also been observed in advanced breast cancers in association with a poor patient prognosis [ 85, 86].
Progressive loss of endothelia in glomeruli and PTC is observed in advanced stages of CKD with renal dysfunction.
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