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The supposition is that greater sequence conservation will be observed for functional as compared to non-functional SLiMs.
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Nevertheless, no differences between the two treatments were observed for functional and overall HRQoL outcomes.
The major difference was observed for Functional Score, where the changes were 24 points versus 34 in the present study.
No effect of the programme was observed for functional or cognitive outcomes and there was no evidence of functional decline in either group.
A similar improvement was observed for functional labels with 11 30 annotations and also for the MF labels in human, yeast and mouse (Fig. 3 and Supplementary Fig. S2).
The opposite trend of increasing transcript abundance from Phase I to Phase III was observed for functional groups that included transcription (11), protein synthesis (12), protein fate (14), protein with binding function (16), and to a lesser extent with interaction with cellular environment (34).
No significant differences were observed for any functional parameters (Supplementary material online, Figure S1A F ).
This was observed for the functional polymorphism R125W in the TBC1 domain family member 1 (TBC1D1) gene.
Between the three conditions significant changes were observed for all functional annotation clusters, except for the cluster of acid phosphatases.
For the FACT-C scales, the only statistically significant difference of the scores was observed for the Functional Well-Being subscale (Δ = +10.0 (SD = 13.2), p = 0.007).
Indeed, a clinical relevant variation was observed for all functional scales by the QLQ-C30, with mean difference superior to 10 points in ten scales and superior to 5 points for all scales.
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