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It might be noticed in passing that the interactions of the inhibitor carboxylate group with the enzyme described above hold the thiazolidine ring of 12 from sterically impeding nucleophilic attack by water on the acyl-enzyme intermediate; the thiazolidine nitrogen is held well away from both boronate hydroxyl groups.
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During these prior phenotyping studies, it was noticed in passing that, following culture and sorting by flow cytometry, the PMs, from the few donors studied, could give rise to tartrate-resistant acid phosphatase-positive (TRAP+) multinucleated cells upon culture in M-CSF + RANKL [ 25].
As time passes, these effects may be noticed in recently invaded areas such as Hawaii and Gabon as well.
Strongest ERP was noticed in condition 1.
Unusual behavior was noticed in March 2006.
Congestions were noticed in enlarged sinusoids.
L1CAM expression was noticed in 15/52 TNBCs.
87 No complications were noticed in registries.
The smoke and light could be noticed by passing aircraft or boats.
This can be noticed by a passing airplane.
Even in silence you can be noticed.
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