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However, it should be noted that analysis of sequences linked to a single date of collection could result in underestimating the true tMRCA.
It should be noted that analysis of any single one of these genes in isolation would not lead to a strong conclusion of positive selection, since none showed a dN/dS value >1.
Accordingly, it should be noted that analysis of this data is limited by the possibility of residual confounding or indication bias not accounted for by propensity adjustment.
It should be noted that analysis of median survival times requires the strong assumption of a constant hazard in each trial arm.
It should be noted that analysis of DNA methylation is often limited to a selection of imprinted genes, which may lead to a biased underestimation of epigenetic changes on the genome level.
However, it must be noted that analysis carried out in countries other than the US and Canada is only preliminary due to the sample sizes and further investigation is needed before any firm conclusions can be made.
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It should be noted that the analysis in "Analysis in the high SNR regime" section is tailored to the high SNR case.
It should be noted that visual analysis is usually performed using a binary scale while quantitative analysis usually involves receiver operating characteristic analysis without prespecified cut-off values in most cases.
It should be noted that FS analysis is an intrusive uncertainty quantification method that requires the user of the method to be familiar with the simulation code structure including numerical spatial and temporal integration techniques.
It should be noted that this analysis is calculated on the starting age of the interventions.
It should be noted that our analysis involves several idealistic assumptions (see Section 2).
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