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Pancreatic cancer cell lines showed significantly reduced cell proliferation and invasion after inhibition of S100A6 and different genes (e.g. human ovarian b-A inhibin, activin A and cytokine gro-b) that are known to be negative regulators of cell proliferation were shown to be up-regulated by S100A6 inhibition [33].
The FGF targets MKP1 and DUSP5 are shown to be negative regulators of FGF signaling in early Xenopus tissues.
Here we examined whether human Sprouty2 (hSpry2) or human Spred (hSpred1 and hSpred2) can be negative regulators of ERK activation induced by cyP (PGA1 and 15d-PGJ2).
Because 3' UTRs tend to be targets for miRNAs, and miRNAs tend to be negative regulators of their targets, it is possible that these two motifs represent a mechanism for both positive and negative regulation of the same process.
As miRNAs are considered to be negative regulators of expression the positive association of miR-150 to the immune response indicates that miR-150 is not a direct regulator of this process but rather a part of the immune response transcriptional program.
Consistent with the anti-proliferation trend identified in MORAN-PD-UP, we also found a slight enrichment for "regulation of growth" genes in LESNICK-PD-UP (p = 0.006), with two genes known to be negative regulators of growth – ING1 and BCL6, shared with MORAN-PD-UP.
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Furthermore, NDRG2 and FOXA2, which are negative regulators of cell motility, were down-regulated.
These kinases are negative regulators of the Cdc28p/Cdc2 CDK kinases that regulate the time of entry into mitosis [ 101- 104].
CCA1 and LHY are negative regulators of TOC1, and TOC1 and CHE positively regulate the expression of CCA1 and LHY.
Tumor suppressors such as p53 can positively regulate autophagy, whereas oncogenic molecules such as mTOR are negative regulators of autophagy.
Phytochromes are negative regulators of miR172d that suppress AP2 genes SNB and OsIDS1, both of which are negative regulators of Ehd1.
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