Sentence examples for be negative modulators of from inspiring English sources

We found that both Nkx2.7 and Nkx2.5/2.7 morphants exhibit overexpression of tbx5 and tbx20 in heart, suggesting that Nkx2.5 and Nkx2.7 may be negative modulators of tbx5 and tbx20 in zebrafish.

Thus, the 3 BCL2 family members are likely to be negative modulators of autophagy.

Ligands of the transforming growth factor-β superfamily, including certain growth and differentiation factors (GDFs), their respective "activin" receptors, and the intracellular signaling proteins Smad 2/3, have been shown to be negative modulators of late-stage erythropoiesis [ 2, 3].

Notably, CSNK1A1 was the highest ranking hit from siRNA screen 3, and 2 additional casein kinase (CSNK) family members, CSNK1G2 and CSNK2A2, were found to be negative modulators of autophagy by siRNA screening (Table S1D), suggesting casein kinases as possible targets.

Nuclear receptors, including ER, are negative modulators of STAT3 in multiple myeloma cells [ 77].

In support of this hypothesis, it has been reported that the two protein kinases positively regulating HKII activity, Akt and myotonic dystrophy protein kinase (DMPK), are negative modulators of autophagy.

Scores of > 5/10 (Question 5) or > 7/10 (Question 9a) on the Likert scale were considered to be negative modulators [ 67].

In rodent models, 5-HT1A receptors are potent negative modulators of female rat sexual behavior.

For example, BAK1 is reported to be a negative modulator of autophagy only in the experimental context of dual BAK1 and BAX knockdown; BAK1 should therefore generally be considered a positive modulator of autophagy.

The first gene, BAX, is reported to be a negative modulator of autophagy only in the experimental context of dual BAK1 and BAX knockdown;, hence, negative modulation of autophagy by BAX may occur only in that rare genetic context, which may not occur frequently in clinical tumors.

When overexpressed Nrf2 was shown to be a negative modulator of mitochondrial mass and membrane potential in a high throughput screen using C2C12 myoblast cells [ 73].