The BCR-ABL1 fusion gene, encoding a constitutively active tyrosine kinase, is thought to be sufficient to cause chronic phase (CP) CML, whereas additional genetic lesions are needed for progression into CML BC.
The notion that only a portion of melanocytes with activated ERK will develop melanoma, suggests that the ERK activation is an initial event in GHM genesis and additional alterations are needed for progression to melanoma.
Although additional genetic events are very likely to be needed for HGSIL to ICC progression, the E2 gene disruption is a putative early marker to consider in the prognostic analysis of HPV 16 chronically infected women.
The low frequency of spontaneous progression of precursor lesions to invasive PDAC suggests that additional genetic aberrations are needed for disease progression (Morris et al, 2010).
One possible explanation is that CAF-1 is needed for efficient progression through the endocycle in trichomes.
Unfortunately, the technique destroys the blood supply at donor site, which is needed for adequate progression of arteriovenous anastomosis.
This leads to an intriguing situation in which the presence of both wt and mutant EZH2 is needed for tumor progression.
Previous work has shown that AKT activity is needed for G1/S progression during the cell cycle, which can be explained, at least partially, by regulation of Cyclin D1 levels [ 12], reviewed in [ 13].
Thus, it is possible that infiltrating neutrophils, and the subsequent recruitment of MDSCs, are needed for the progression of liver metastases by dampening anti-tumor immune responses and promoting a pro-angiogenic microenvironment [ 78].
This ability of the S83A-HP1γ mutotion to mimic conditions of absolute HP1γ depletion at the level of gene expression networks, combined with the inability of the S83A-HP1γ mutont to rescue the mitotic defects observed with HP1γ knockdown, indicates that posttranslational modification of this residue is needed for proper progression through mitosis.
