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85 86 More data will be needed for full appreciation of the health economic aspects of TCZ use.
This is important as more data are accumulating to suggest that other hurdles, besides just induction of IE1/IE2, may be needed for full reactivation of infectious virus.
Third, viral sequences suggest the possibility of resistance to certain antiviral medications, rendering some current treatments ineffective., And fourth, viral isolates bear hemagglutinin receptor binding site mutations that better enable this avian virus to infect mammals, and only a few additional mutations might be needed for full adaptation for human-to-human transmission.
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That is only a fraction of the billions of dollars that will be needed for full-scale restoration.
This effect should be taken into consideration in designing of composites (in calculation of the amount of Al which is needed for full infiltration).
The toxin bound reversibly to α2B-adrenoceptor, but extensive washing was needed for full recovery of binding sites at high toxin concentrations.
In addition, gain-of-function analysis demonstrated that the fragment (−409 to −337) coupled to the W-box-like element was needed for full magnitude of the fungal induction.
Additional investigations are needed for full in vitro recapitulation of the assembly process, in presence of all three capsid proteins and the viral minichromosome.
It is therefore possible that while double administration of antibody is needed for full protection in the guinea pig model, in humans, a single administration will provide equivalent and long lasting protection.
A 5 mM concentration of HM is needed for full inhibition of bacterial adhesion in vivo (Figures 7 and 8), versus a 1 mM concentration in vitro (Figure 6).
Interestingly, mutations in syx1A abrogate the shape of the apical plasma membrane and the secretion of cuticle proteins, but not chitin synthesis that occurs at the plasma membrane suggesting that a second apical SNARE is needed for full aECM production.
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