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Taken together, data presented here argues that hHR23a presence may be necessary to modulate and regulate BCA2 in a cancer setting.
In other words, these results suggest that germ mutations seem insufficient to induce higher breast cancer risks by themselves, but environmental interaction would also be necessary to modulate gene expression related to familial breast cancer.
To prevent or to reverse adverse epigenetic alterations associated with multifactorial aging diseases, combinatorial therapeutic and/or nutritional approaches will be necessary to modulate different classes of chromatin modifiers.
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Based on the aforementioned studies' findings [14,15,35], it could be hypothesized that major weight loss connected to exercise training is necessary to modulate inflammatory gene expression levels in PBMC.
There is general agreement among the health care community that incorporation of effective, evidence-based treatments into guidelines is necessary to modulate clinician behaviour and to ensure uniformity of treatment within different hospitals and between individual doctors.
Knowledge of the recognition specificity of σ factors and assignment of σ factors to particular promoters is necessary to modulate the effects of sigma factors on the production of specific metabolites.
In order to improve the SINR of the radar system and an acceptable BER of HP communication system, it is necessary to modulate the spectrum of radar sequences to make sure that the integrated energy over the frequency hopping channels is under acceptable level.
Our longitudinal design allowed for examination of two perspectives on the interplay of reactivity and regulation, namely that (a) early negative affectivity interferes with the development of later regulation and (b) regulation is necessary to modulate negative affectivity and, thus, would buffer the effects of negative affectivity on later regulation.
Interestingly, co-expression of XopD1-760 in these assays led to a stronger repression of PR1p transcriptional activation, suggesting that the N-terminal extension of XopD is necessary to modulate XopD function in the host (Figure 6A).
For example, microinjection of a COX inhibitor into the preoptic area of rat brain, a region believed to be responsible for thermoregulation, decreased the fever response to LPS suggesting that prostaglandin biosynthesis in that region of the brain is necessary to modulate the thermoregulatory response to infection [26].
3) We have performed additional experiments to show ASN is necessary to modulate motor neuron activities.
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