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In these circumstances, it will often be necessary to fall back on PNS as the only effective and feasible strategy for Down's prevention.
When the preventability index is low, as it is for hospital mortality and many other outcomes in healthcare, it may be necessary to fall back on direct measurement of process and outcome by examining individual cases in detail for example, by case-note review.
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As Camus put it, "It is necessary to fall in love … if only to provide an alibi for all the random despair you are going to feel anyway".
Axes, saws, wedges and sledges may be all that are necessary to fell the trees and shrubs and cut them into the desired lengths.
A sample size of 500 will be necessary to see an effect on falls rate.
Although it may be hard to sit still being so nervous before your race, it is necessary to not fall into the trap of warming up too much.
In contrast to current recommendations that advocate a reduction of 30% (35), we found a 50% reduction was necessary to prevent falls in blood glucose early after exercise.
When the banking crisis led to the collapse of demand in the economy in 2008-2009, the deficit was necessary to prevent the fall from becoming even steeper.
So I told her that falling was a part of the process and she was not to get mad or blame me or herself for falling, because not only was it normal to fall, it was necessary to learn.
Let the companies explain why it was necessary to assure that a falling stock price did not hurt the bosses.
This is necessary to avoid civilian casualties (falling 50kg sacks can cause serious damage and airdrops have killed civilians in Afghanistan and elsewhere), and ensure aid can be collected by ground teams.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com