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To trigger fusion, it may not be necessary to dissociate the H3 motif completely, it may only be necessary to enhance fluctuations at the N-terminus or bring the other SNARE partners into close proximity to the more dynamic syntaxin N-terminus.
In particular, determining the precise contribution of changing endocytic rate to short-term release dynamics will not be trivial, in part because it will be necessary to dissociate the effects of altered endocytic rate from other influences on release dynamics including calcium dynamics and vesicle pool dynamics.
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As phosphorylation at both T86 and T398 is necessary to dissociate Sin1 from the functional mTORC2 complex, substitutions at R81T or S84L diminished the possibility of co-occurrence of pT86 and pT398, resulting in stabilized mTORC2 integrity and function (Fig. 3).
To obtain a large number of BrCSCs, it is necessary to dissociate the optimal size of tumorspheres into single cells.
The electric field strength that is necessary to dissociate sufficient condensed ions to render a nematic domain unstable, depends critically on the ambient ionic strength of the dispersion without the external field, as well as the rod-concentration.
It is necessary to plate freshly dissociated embryonic cells on a solid substrate to promote differentiation and to prevent clumping.
A transformation of the variance was thus necessary to dissociate the information it provides from that provided by the mean.
When performing a visuomotor task it is necessary to integrate visual and kinesthetic information that may be spatially dissociated.
"Mine was necessary to me.
"It was necessary to you".
Babies are necessary to grownups.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com