It is necessary to critically examine the impact of a new generation of PIT technologies, which may exacerbate the red cell storage lesion and cause the development of undesirable antibodies in the recipient.
In order to fully realize this potential, it is necessary to critically assess the capabilities of current experimental methods in elucidating whether and how the mechanics of living cells and biomolecules, under physiological and pathological conditions, plays a major role in health and disease.
To understand this point, it is necessary to critically reflect on the definitions of the key concepts at the heart of the field of hazard, disaster, and disaster risk reduction.
Regarding the transition to competitive bidding processes as promoted in the EU energy aid guidelines, it is necessary to critically discuss the question of how a stronger integration of different RES in existing electricity markets can actually contribute to improving security of supply, reducing the costs of RES expansion and transforming the electricity system.
When a new treatment becomes available, especially one with a higher cost but greater benefit than usual care, it is necessary to critically appraise the cost-effectiveness of this new treatment to determine whether the improvement in treatment efficacy makes financial sense, especially in the era of limited healthcare resources.
When making comparisons of the prevalence of wheeze or asthma between different studies, it is necessary to critically assess the content of the question.
In order to propose which site(s) may be optimal for chronic ventricular pacing in children, it is necessary to critically appraise the various pacing sites in the context of mechanical activation patterns and cardiac function.
Not discounting the importance of these key indicators, it is necessary to critically examine the primary MCH measures used to assess the effectiveness of MCH programs for enhancing the health and wellbeing of Aboriginal and Torres Strait Islander women and infants.
Again, further protein-based analyses will be necessary to characterize the biological significance and critically evaluate the hypothesized functional equivalence of the F-specific ORFs in bivalves.
Although Bayesian mixing models are very powerful tools, it is necessary to test critically whether the model outputs concur with common physiological and ecological knowledge (Layman et al., 2012).
