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Considering that NG2 cells also exhibit a strongly hyperpolarized membrane resting potential (−80 to −100 mV), the synchronized activation of many synapses would then be necessary to activate either voltage-dependent calcium channels or sodium channels.
In addition, interaction with extravascular cells and smooth muscle cells may be necessary to activate the signaling pathway that couples changes in arteriolar oxygen pressure to changes in arteriolar tone [55].
Since males show behavioral aggression even in the non-breeding season, an increase of systemic T upon social interaction must not be necessary to activate aggression in this species; although it may increase the intensity and persistence of the behavior [17].
The concentration range seems to be necessary to activate H2O2-dependent signaling pathways stimulating the expression of H2O2 responsive genes [ 26].
28 More recently, HDAC3 has been shown to be necessary to activate IL-4 and loss of HDAC limits IL-4 mediated allergic disease.
Our hypothesis was that N-Myc might be necessary to activate neuroblastoma differentiation (mimicking embryonic development events) by regulating certain non-coding RNAs critical for differentiation.
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In monolayer culture, autocrine EGFR activation is necessary to activate AKT [ 30], so we determined whether autocrine EGFR activation is necessary for AKT activation in organotypic culture.
Cbl is a substrate for nonreceptor tyrosine kinase Src, and phosphorylation of Cbl is necessary to activate its ubiquitin ligase activity [ 24].
As a consequence less activation is necessary to activate the corresponding word.
In fact, we observed a substantial drop in DEVD-AMC cleavage activity, which might be explained by the observation, that proteasome activity is necessary to activate caspase-3 at least in some cells [ 66, 67].
On copper, a redox cycle of the metal is necessary to activate the catalyst.
More suggestions(17)
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be necessary to engage
be necessary to enable
be necessary to implement
be necessary to accelerate
be necessary to trigger
be necessary to select
be needed to activate
be necessary to kick start
be necessary to raise
be necessary to destroy
be necessary to create
be necessary to make
be necessary to endure
be necessary to cope
be ready to activate
be necessary to note
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