However, having such information is necessary for validation of computational models.
Longitudinal studies are necessary for validation of data and to further clarify the relevance of TMV.
Further testing in a larger study is necessary for validation of these results.
A larger study with subjects representing various age groups 20-300, 30-40…80-90 y. o). is necessary for validation of these initial findings.
Future observations will be necessary for further validation and to study the time evolution of the displacements, and supplementary research must be conducted to determine the possible causes, in particular if they are connected with the water pumping operations performed on the island.
Note that the validation methods used in this pilot study ((i) leave-one-out cross-validation and (ii) randomly blinding 25% of the data after building the DFA models with the entire data) did not accommodate an independent sample set that would be necessary for blind validation.
Furthermore, functional follow-up tests will be necessary for a full validation of their adaptive significance (Lang et al. 2012).
In addition, the networks were built solely by a bioinformatics approach and experimental verifications will be necessary for their final validation.
Further work will be necessary for external replication and validation of these results.
Further well-designed human studies are necessary for proper validation.
