Sentence examples for be necessary for substrate from inspiring English sources

Evidence for the vestibular, or S2, pocket serving as the initial substrate binding site was provided with the dopamine transporter, in which two dopamine molecules were seen to be necessary for substrate translocation through the cell membrane.

Residues have been identified that are necessary for substrate interaction, and these observations have suggested a structural model for this reaction.

Deletion of recognized domains of DNMT3A reveals that the conserved PWWP domain is necessary for substrate inhibition and forms at least part of the allosteric DNA binding site.

Comparison with other family PL-7 structures indicated that loop opening is necessary for substrate binding when the catalytic reaction is initiated.

The AR protein binds the C-terminal lobe of APH and thereby stabilizes three α helices, which are necessary for substrate binding, in a significantly displaced conformation.

We found that the conserved Tyr124 in Loop 1 was essential for catalysis while Tyr126 was necessary for substrate specificity.

Moreover disulfide bond C233 C247 is located in the first Fibronectin type II domain and this domain is necessary for substrate binding.

The p20 and p10 units are necessary for substrate recognition and catalytic activity.

This unanticipated conformation was identical to that observed in the postautoproteolysis structure of wild-type ThnT and is necessary for substrate binding in the mature enzyme.

Therefore, while Trp107f is necessary for substrate specificity in the apicomplexan enzymes (as indicated by the alanine scan mutations), it is insufficient to confer specificity.

Located at the tip of loop β6, the residue's phenyl side chain seems to restrict rotational movement of neighboring Y375 whose reorientation is necessary for substrate binding in native OYE1.