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As data generated from some viral systems other than coronaviruses suggested that viral N N self-interactions may be necessary for subsequent formation of the nucleocapsid and assembly of the viral particles, we decided to investigate SARS-CoV N N interaction.
Figure 4 depicts different destinations for the endosomal cargo, and early escape appears to be necessary for subsequent gene activity.
Additional alterations (genetic and epigenetic) are believed to be necessary for subsequent steps toward invasiveness, such as those identified with recent genome-wide analyses [ 7, 8].
Dysfunctional AEL processes may thus not only be necessary for optimal and preferential Aβ1 42 accumulation, but also may be necessary for subsequent neurodegenerative mechanism(s) in Drosophila.
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The detailed data both on silicon inclusions and oxide matrix properties are necessary for subsequent performance optimization of these nanostructures.
The activation of both leukocytes as well as endothelial cells occurs, and is necessary for subsequent emigration [3], [4], [5].
Digestion with commercial PNGase F at pH 7.0 (the neutral pH is necessary for subsequent experiments) usually takes 16 24 h to release the oligosaccharides from the glycoproteins [29], [30], [31], [32].
The initial selection for the TRP1 plasmid is necessary for subsequent selection of FOAR isolates [ 14].
Accurate binding locations are necessary for subsequent functional analysis and discovery.
An equally plausible case can be made for interdependency whereby inflammation initiates a cascade of events that is necessary for subsequent neurodegeneration [ 5- 7].
SXR activator-induced increases in iNOS levels were inhibited by siRNA-mediated knockdown of SXR, indicating that SXR activation is necessary for subsequent regulation of iNOS expression.
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