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Another, Chesler and Bönnemann note, is that proprioception itself might be necessary for normal skeletal development.
An 880 bp fragment located approximately 10 kb upstream of the gene and containing the NACP-Rep1 polymorphism, was shown to be necessary for normal expression.
They may represent a disrupting feature of sleep but may also be necessary for normal, healthy sleep and are associated with autonomic activation [84].
APP cleavage and signaling also occur during brain embryogenesis and seem to be necessary for normal brain development [9] [11].
Studies on the physiological role of the PrP gene (mostly in knockout mice) have found that the gene may be necessary for normal functioning of several nervous system processes, circadian rhythm, survival of some nervous cells and may be related to oxidative stress and post-hypoxia neuronal responses [26] [29].
Similarly, GTP binding protein EngB is reported to be necessary for normal septation and its disruption leads to extensive filamentation.
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Paolicelli, R. C. et al. Synaptic pruning by microglia is necessary for normal brain development.
Paolicelli, R.C. et al. Synaptic pruning by microglia is necessary for normal brain development.
HCN channels expressed in the inner ear are necessary for normal balance function.
For example, receptor-mediated endocytosis enables cells to ingest molecules such as proteins that are necessary for normal cell functioning.
Research shows that environmental enrichment is necessary for normal visual, auditory, and somatosensory development.
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