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Thus, a functional T4SS might not be necessary for developing duodenal ulcer.
However, loss of appetite does not seem to be necessary for developing cachexia, as already described in the past [ 4].
Further, understanding the molecular mechanisms leading to GTN will be necessary for developing targeted therapies for chemoresistant GTN.
Conversely, selective inhibition of a particular PI4KIII isoform might be necessary for developing a well-tolerated anti-hepatitis C viral therapy [ 15, 16].
A genetic predisposition seems to be necessary for developing the disease and is most often linked to genes in the HLA-complex [ 1].
Rather, a partnership approach between patients and providers, based on shared decision making and good communication, may be necessary for developing a sense of confidence and ability to change [ 12, 16].
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Identifying user requirements is necessary for developing a user-oriented product, but it is equally important to apply a development process that allows the project team to fulfil these requirements.
In some instances private enterprise is used; in others, government provides the facilities and equipment, especially if the rationale for government involvement is that a strong transportation system is necessary for developing the nation's economy or for its defense.
For practical application of MFCs to WWT, further studies are necessary for developing technologies for the production of large and cheap electrodes.
This information is necessary for developing a more fundamental understanding of chemical dispersion of crude oil at low salinity.
Mobility research has found, for example, that interactions involving physical co-presence are necessary for developing extended relations of trust (Urry, 2002).
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CEO of Professional Science Editing for Scientists @ prosciediting.com