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In wt αB crystallin, the 3D organization of the interactive sequences may be necessary for coordinating their collective activity in response to cell stress and in control of microtubule assembly during cell proliferation.
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Further fields like hybridization or coordinates might be necessary for some algorithms but instead of cluttering Atoms with lots of optional fields, we argue that in those cases a more specialized class should be used which will lead to an increase in terms of type-safety.
"Won't be necessary for either".
These will be necessary for heavier jobs.
In addition to repressing the expression of several collagen transcripts, we also found that FoxO was necessary for the coordinate increase in the gene expression of matrix metalloproteinase 8 (Mmp8) and Mmp9 in muscles of cachectic tumor-bearing mice (Table 2 and Additional file 3: Table S1), which participate in the degradation of Type I, II and III collagens and Type IV collagens, respectively.
Re-evaluation of the output was necessary for those coordinates that present 2 or more candidate SNVs.
For Affymetrix data, both log and Z-transformation are required in Step 1: The log-transformation gives data a more symmetric distribution, and Z-transformation itself does not affect the individual t-statistic for each gene and is necessary for transforming the coordinate axes.
Both positions were necessary for offset correction and coordinate transformation to correct for possible orientation errors of the sensor.
6 Therefore, it is necessary for clinicians and patients to coordinate and participate in rational use of antidiabetic drugs.
Thus, a systems level view is necessary for understanding how a cell coordinates this process and for developing effective therapeutic strategies to treat diseases, such as cancer, in which differentiation plays a significant role.
However, coordinating them is necessary for proper and effective global administration.
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CEO of Professional Science Editing for Scientists @ prosciediting.com