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The gene MKI67 encodes Ki-67, a nuclear protein that is associated with and may be necessary for cellular proliferation.
Lately, bacterial homologues of eukaryotic STP have been shown to be necessary for cellular functions such as growth, differentiation, pathogenicity, and secondary metabolism.
Its expression is thought to be necessary for cellular immortalization (Rhyu 1995), and its absence may constitute a fundamental basis for cellular aging (Harley et al 1990; Ahmed and Tollefsbol 2001; Artandi 2006).
Since the majority of Tax-responsive cellular genes are important regulators of cellular proliferation, the transactivating functions of Tax appear to be necessary for cellular transformation by HTLV-I.
In differentiated chondrocytes exposed to oxidative stress, loss of the forkhead transcription factors FoxO1 and FoxO3 in combination with decreased SIRT1 activity lead to cell death with reduced production of autophagic related proteins, indicating that SIRT1 with FoxO proteins may be necessary for cellular survival [ 120].
As activation of even a subset of EMT-associated processes may be sufficient to confer increased motility or resistance to apoptotic stimuli without complete conversion to a mesenchymal cell, it may be necessary for cellular mediators that regulate EMT to be sufficiently flexible to inhibit many different targets - a job that is perhaps particularly well suited for miRNA.
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Medium supplementation for culture cells with fetal bovine serum is necessary for cellular growth.
The understanding of the functioning of an essential member of the cytochrome P450 family, which is necessary for cellular detoxification, was also facilitated.
Indeed, Ptbp2 ablation in germ cells resulted in disorganization of the filamentous actin (F-actin) cytoskeleton in Sertoli cells, indicating that alternative splicing regulation is necessary for cellular crosstalk during germ cell development.
Each AR domain co-ordinates a multitude of individual and vital roles via a diverse array of interacting partner molecules that are necessary for cellular and tissue development and maintenance.
Selenium salts are toxic in large amounts, but trace amounts are necessary for cellular function in many organisms, including all animals, and is an ingredient in many multi-vitamins and other dietary supplements, including infant formula.
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