Sentence examples for be necessary for activity from inspiring English sources
The mechanisms proposed by Hashimoto et al. and Martinez et al. involve mainly α-subunit residues and particularly the cysteine-sulfenate oxygen, known to be necessary for activity, to act as a general base in activating a water molecule to attack the metal bound nitrile or as the nucleophile itself, respectively.
This may introduce a potential limitation in our study, as bacteria-expressed Cyr61 may not display functionally important glycosylation that may be necessary for activity or take part in the folding of a particular (micro domain of the protein.
The C-terminal β-sandwich domain is shown to be important both for oligomerization and activity, indicating that at least a dimeric form may be necessary for activity.
The presence of the SH2 domain as well as the linker region between SH2 and kinase domain has been shown to be necessary for activity of Itk and, by analogy, also for the activity of other Tec family members (Tec, Btk, Txk and Bmx).
In home environment, context knowledge is necessary for activity analysis.
Structure activity relationship studies using novel analogues of 1 3 revealed that two phenylsulfonic acid moieties were necessary for activity and that the carbon carbon double bond of the stilbene sub-series was the optimum spacer connecting these groups.
Additional promoter constructs were used to show that the promoter consists of two discrete elements, A and B, both of which were necessary for activity.
The modified cysteine residues are necessary for activity.
The distant elements of the substrate were necessary for activity as truncated substrate -26 was not dehydrated by TylDH3.
By comparing the structures at the top of each cliff with those at its base, we could infer which structural features are necessary for activity.
Initial identification of desmosdumotin B showed that co-incubation of verapamil reversed the collateral sensitivity of KB-VIN cells, suggesting that functional P-gp was necessary for activity.
