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Although the optimal beneficial cell dose is high, a better approach may be multiple administrations of smaller cell doses, an approach we plan to take for our next study.
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No accumulation potential was therefore found after multiple administrations of luseogliflozin for 7 days.
In these patients, multiple administrations of furosemide were associated with an increase in arterial BE (P = 0.001), pH (P = 0.01) and plasmatic SID (P = 0.01), due to a reduction in plasmatic [Cl−] (P = 0.009, Table 3).
This pattern of ERK activation might be associated with distinct effects on regulating mitochondrial turnover versus biogenesis between acute and chronic MPP+ models, and explain why multiple administrations of MPTP are typically needed to elicit parkinsonian injury in mice.
PK parameters of TAK-875 were also constant over time after multiple administrations of 200 and 400 mg doses in healthy subjects.
The primary outcome measure was the safety and tolerability of multiple administrations of solanezumab, with pharmacokinetic and cognitive assessments as secondary endpoints.
Longer term studies are necessary to evaluate the transduction efficiency following multiple administrations of Sendai vectors.
Exclusion criteria were: history of chronic kidney disease, AKI with or without renal replacement therapy (RRT) before administration of ICM, and multiple administrations of ICM.
Regarding adverse events in cancer vaccines, previous studies on cancer vaccines with various forms of vaccine antigens have rarely reported the incidence of adverse events associated with autoimmune reactions even if immune responses against vaccine antigens were clearly detected after multiple administration of vaccines.
It is important to investigate whether multiple administration of the therapy will invoke further salutary effects to the infarcted heart.
Similarly, after multiple administration of edoxaban, 77.0 % of TEAEs were mild and no serious adverse events were reported [ 19].
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