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The cause of this disease appears to be multifactorial and involves genetic as well as environmental aspects.
Although the exact pathogenesis remains unknown, OA of the knee is believed to be multifactorial and involves the whole joint.
The basic underlying cause of endometriosis is likely to be multifactorial and involves interplay between several factors.
Phototoxic retinal damage appears to be multifactorial and involves several mechanisms of action depending on the chromophore involved in the bright damage.
Given that the cause of airway inflammation can be multifactorial and involves a multitude of cell types and inflammatory mediators, the medications used to control inflammation may act at several different points in the inflammatory pathway[ 2, 5].
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Taken together, these results suggest that the negative impact of proteases on biofilm formation may be multifactorial and involve both attachment and accumulation.
The causes of damp-building syndrome are likely to be multifactorial and involve toxic, inflammatory, and allergic responses to microbes and their products; however, the underlying mechanisms, relative contributions of individual organisms, and potential for interactions remain poorly understood (IOM 2004).
The etiology of diabetes associated cognitive decline is multifactorial and involves insulin receptor down regulation, neuronal apoptosis and glutamatergic neurotransmission.
In these cases the pathophysiology for headache is multifactorial and involves the direct activation of nociceptive sensory afferents innervating the intracranial vasculature, the release of vasoactive neuropeptides from sensory afferents and of inflammatory cytokines from damaged tissue.
The pathogenesis of AKI is multifactorial and involves hemodynamic, inflammatory and nephrotoxic components [ 7].
The mechanism of colorectal cancer immune evasion is multifactorial and involves also defects of dendritic cells.
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