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It is certainly presumptive to predict the future; however, it may be more permissible as a wish, rather than a forecast.
An initial explanation would be that the discrepancy is due to differences in the number and/or location of the transgene integration site(s), especially given that specific loci appear to be more permissible than others.
Similar(58)
Transcriptional activity is correlated between genomic regions residing near each other [ 51- 53], and the observation that piRNA targeting of RTEs is higher around highly expressed genes, may simply reflect that transcription of RTEs is more permissible near highly expressed genes.
This pattern could arise if the regulation of some genes has been selectively constrained over long periods of evolutionary time, whereas others have been more permissible to genetic perturbation.
As with most structural genes, genetic mutation is more permissible than in non-structural genes, and as long as the function of the protein is preserved, there can be a larger amount of diversity before the gene renders its virus non-viable.
In both groups, non-permissible deviations were more common than permissible deviations (that is, toxicity and comorbidity); however, the proportion of deviations that were non-permissible was lower among patients who achieved remission compared with those who did not (8.0 versus 16.9%, P <0.0001).
The area nearer to this point having arsenic value is more than the permissible limit.
The GIS analysis of the spatial variability of alkalinity indicates that alkalinity value is more than the permissible limit.
In the case of the 316 stainless steel backwall, the maximum thermal stress was more than the permissible stress (164 MPa).
If the concentration of magnesium in drinking water is more than the permissible limit, it gives unpleasant taste to the water.
The area of high concentration of fluoride is indicated by purple color having fluoride value that is more than the permissible limit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com