Several reviews described a negative correlation between study quality and outcome (better studies were more often negative; for example [ 9, 11, 13]).
Although land grabs can have a positive impact on local communities, findings from sub-Saharan Africa indicate that the results are more often negative (48).
Finally, their experiences of healthcare services are more often negative, and sometimes they feel judged by the professionals providing their care [ 11- 15].
Another source of bias in the specificity estimate could be that the 15 20% specimens that were not tested on day 7 were more often negative on day 4 than were the specimens that were tested on day 7.
Lastly, one clear observation from our analysis was that score changes as a result of discussion were more often negative than positive, which is similar to what others have found.
Both ER and PR receptor status were more often negative in the BRCA1 related group (72.7% and 75.4% for ER and PR respectively, compared to 48.3% and 54.5% in controls; P = 0.005 and P = 0.016, respectively).
We could not correlate PPAR γ staining with any of the prognostic variables analysed in the group of PTCs, except for tumours presenting a predominantly follicular pattern that were more often negative (80%) than classic PTCs (28%; P=0.01).
In general, for chemical analytes measured in blood, effect estimates for albumin were positive, and their inclusion increased the LSGMs for pregnant women; in contrast, for nonpersistent urinary chemical analytes, the albumin effect estimates were more often negative, and their inclusion decreased the LSGMs for pregnant women (data not shown).
In a study of 2 163 456 respondents from 8267 English primary care practices we show that case-mix adjustment of practice-level scores results in relatively few large adjustments (which were mainly positive), and many small adjustments (which were more often negative).
BRCA-associated tumours, which are more often of higher grade than that of sporadic breast cancer, would therefore be predicted to be more often ER negative.
