Thus, the question if differential entropy selects for genes that are more frequently altered and how the directionality of change might relate to the type of alteration is still an open question that we hope to address in future studies.
In this figure, areas indicated in green are more frequently altered in SCLC while those in red are more frequently altered in NSCLC.
Furthermore, 3p21-p14, 6p, 8p22, 11q, 13q14, and 17q21 were more frequently altered in IBC than in non-IBC.
The genes were more frequently altered in squamous cell carcinomas than in adenocarcinomas and a set of seven potential markers is promising for discrimination between the two malignancies.
In contrast, P53 pathway was more frequently altered in HBV-HCC and the TP53 gene was the most frequently mutated gene in HBV-related HCC (41%), whereas it was rarely mutated in non-HBV tumours (16%, p=0.0002).
ANOVA analysis identified AXIN2, which plays an important role in Wnt signaling pathway cooperating with APC and b-catenin, being more frequently altered in Group 2 that included the serrated adenomas.
In addition to copy number changes, LOH of chromosome 17 [ 36] and regions 6q25-q27, 8q24, 9p21, 13q14, and 17p13.1 are more frequently reported in poorly differentiated DCIS [ 34], whereas LOH of chromosome 16 [ 36] and 16q22.3-q24.3 were more frequently altered in low-grade DCIS [ 34].
We would expect that nodes exhibiting the most significant increases in entropy may point to genes and signalling pathways that are more frequently altered in the metastatic or poor prognosis breast cancer phenotype, irrespective of the modality of the underlying alteration.
Act genes should be more frequently amplified and receive protein-affecting non-truncating mutations, which may increase and/or alter the protein function.
Environmental disturbance regimes are more frequently being altered by historically novel events and disturbance interactions, which may trigger reorganizations of new ecosystem states and processes.
