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At present we provided "proof-of-principle", it is clear that our procedure as well as the data need to be more extensively validated in the future before the method can be broadly used as an alternative for the classical biopanning and as a new platform for rapid screening of ligands.
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There is no clear difference in diagnostic performance between using another clinical prediction rules, but the score by Wells and colleagues has been more extensively validated.
If more extensively validated, these data would suggest that RB loss could be specifically used to define patients whose tumors would be most apt to respond to optimized chemotherapy regimens.
The paper is more extensively illustrated.
Edison, of course, is more extensively associated with his inventions.
The QCancer model has been externally validated and is one of the models applied in electronic cancer decision support (eCDS) (Dikomitis et al, 2014) evaluated in over 500 general practices in the United Kingdom; it is currently being more extensively implemented.
This point is more extensively addressed in the discussion section.
Primary care has been more extensively studied than hospital care.
These methods are more extensively described elsewhere [ 18].
But before any clinical applications, miRNA profiling studies require to be extensively validated and more standard, reliable and reproducible platforms will need to be developed.
Models were developed using genetic function approximation technique and were extensively validated employing different validation statistics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com