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Ideally, the next generation of treatments for nosocomial and community-acquired infections, including those caused by Candida spp, Aspergillus spp, Cryptococcus spp and Fusarium spp, will be more efficacious, with higher therapeutic indices and broader activity spectra than existing antifungal drug classes.
The combined regimen thus tended to be more efficacious with respect to tumour control at the expense, however, of increased toxicity which per se, eliminated a potential improvement of the overall therapeutical results.
In our study, we found treatment of live-compromised/damaged cell mixtures to be more efficacious with 100 μM of PMA, a concentration that was two- and tenfold higher than that used by Nocker et al. [ 15] and Contreras et al. [ 44], respectively.
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Biannual alpha-foetoprotein/annual ultrasonography, the most commonly used strategy in the United States, was more efficacious, with a cost-effectiveness ratio of $33 083/quality-adjusted 083/quality-adjusted alife-yearoprotein/ultrasonography.
Iron isomaltoside 1,000 was more efficacious with higher cumulative doses of >1,000 mg IV.
In contrast, DDP followed by DXR was more efficacious with the best cell kill at a 1 h interval between each drug.
A dose response relative to the primary end point, change in Hb from baseline to week 8, was found within group A, where iron isomaltoside 1,000 was more efficacious with higher cumulative doses of >1,000 mg.
Since gallbladder cancer and cholangiocarcinoma are distinct clinicopathologic entities (despite being grouped together in most clinical trials), it is possible that erlotinib plus chemotherapy may be more efficacious for patients with gallbladder cancer than those with cholangiocarcinoma.
So it stands to reason that dexmedetomidine may be more efficacious than lorazepam with regard to acute brain dysfunction in patients with sepsis.
Some studies have found this liquid feed to be more efficacious and associated with lower total cholesterol than a solid ketogenic diet.
In addition to its relevance to culture confirmed enteric fever, another major strength of this large randomized study is that gatifloxacin proved to be more efficacious than cefixime with respect to fever clearance time and failure rates, even in the subgroup of patients who were clinically presumed to have enteric fever but who had a negative blood culture.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com