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Longer-acting antimalarials with a duration of action similar to that of mefloquine and SP are likely to be more efficacious, since they would provide a substantial period of post-treatment prophylaxis.
This approach was chosen for two reasons: (i) Farber disease is progressive and early treatment will likely be more efficacious since it can prevent rather than reverse pre-existing disease, and (ii) ACDase is a soluble lysosomal enzyme that can be secreted from the genetically modified cells and taken up by non-transduced cells through a receptor-mediated mechanism.
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Topiramate, propranolol and divalproex may be more efficacious than other prophylactic medications.
Passive interventions are typically considered to be more efficacious than active interventions (Haddon Jr. 1980).
Our NMA suggested that topiramate, propranolol and divalproex may be more efficacious than other prophylactic medications.
In a more recent study the combination of paracetamol + codeine has been shown to be more efficacious than ASA [91].
In fact, PT treatment was found to be more efficacious when compared to A treatment in many outcome measures.
Whether clonally-derived MSC versus specific MSC populations will be more efficacious for particular applications, remains to be determined.
Since extinction is a major component of nearly all behavioral therapies for human fear disorders, this finding supports the notion that therapeutic intervention beginning very soon after a traumatic event will be more efficacious.
It is possible that higher dosages of siRNA may be more efficacious.
We suggest that combination of PrEP and vaccines might be more efficacious than either intervention alone.
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