But he says the new treatment will probably be preferable, not just because it is more efficacious but also because, unlike the vaccine, it's not based on a replicating livestock virus.
If, on the other hand, one of the options evaluated was more efficacious but more costly than the alternative, the incremental cost-effective ratio is calculated relative to the less costly alternative.
Doublets are more efficacious but more toxic than FU alone, so it is uncertain whether it is better to start with a doublet or to use the drugs sequentially; in addition, doublets are more efficacious than FU alone only in patients under age 70, with a good performance status (PS) and relatively normal serum chemistries (Knight et al, 2000).
128 An exploratory clinical trial has suggested that induction with 1,600 2,000 mg of fluconazole would be more efficacious, 126, 129 but additional evaluation of these doses is required.
For example, TVR and boceprevir were compared in a MTC meta-analysis [ 23], and the indirect evidence suggests that TVR may be more efficacious for prior relapse but not for treatment naïve patients.
A recent meta-analysis concluded that cumulative evidence at the present time does not support routine fusion, whereas a recent systematic review concluded that surgery may be more efficacious than unstructured care, but may not be more efficacious than structured cognitive-behavioural therapy.
We are expecting that such drug products will prove to be more efficacious within the targeted disease process, but also free from unwanted side effects and toxicity.
In comparison with dronedarone, amiodarone may be more efficacious for maintenance of sinus rhythm, but it has a poorer side-effect profile, particularly with long-term use.
A perioperative goal-driven approach may thus be more efficacious - and safer - than empiric administration, but this should not be freely extrapolated to other conditions.
