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As the weak operon proteins have more interaction partners and participate in more pathways, they may actually be more constrained with respect to evolution.
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It's fine when you have really good sites in London where you can deliver on big pieces of land but most of the sites are more constrained with railway viaducts, A-roads, and all the things we want to keep".
Likewise, human paralogs with synonymous divergence between 0.05 and 0.1 have a Ka/Ks ratio of about 0.47 but those with synonymous divergence between 0.1 and 0.5 are more constrained with a Ka/Ks ratio of about 0.37 [ 35].
"But he would find that his sphere of influence would be more constrained to the coaching".
I think we have to be more constrained in terms of our ambition.
First, maternal imprinting may be more constrained than paternal.
"She has had to learn how to live with that and be more constrained.
In addition, the parameters that do not form part of any loop (k1, k2, k3, k10) are more constrained in architectures with essential positive feedback loop than in topologies with an essential negative feedback loop.
Our results indicate that polymorphisms in introns and noncoding sequences in the immediate neighborhood of CDSs (UTRs) are more constrained on average, compared with polymorphisms at synonymous sites and at noncoding sequences further away from CDSs.
Expression breadth is also significantly correlated with d N/d S, with broadly expressed genes being more constrained on average (fig. 3).
Thus in the theater Anderson was more constrained to focus on his true gifts, was less able to maneuver the text with personal angst.
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