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Finally, diagnostic procedures may be more clinically valid when conducted in a clinical setting.
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Whilst HOMA-IR may be considered more statistically valid, the use of IR as a binary variable is more clinically useful and so both outcomes are presented here, with results that were consistent using both approaches.
The study also proved that caseload midwifery is more clinically effective.
However, the less-adjusted statistics are more clinically relevant.
We therefore expected the results on HDRS to be a more clinically valid compared to the BDI results—but we cannot exclude that breaking of blinding and biased assessment of the HDRS may have occurred.
A more clinically valid classification of this pre-dementia state may be Aging-Associated Cognitive Decline (AACD; [ 32]), which has clearly defined diagnostic criteria and requires impairment in multiple cognitive domains [ 30, 31].
By projecting the data over 10 and 20 years, the authors hypothesized that because the model would produce "real cost-effectiveness results in terms of cost per EDSS month of disability prevented", it may be more "valid and more clinically meaningful than cost-utility ratios".
"I think we're moving from a SNP world where the associations are weak and questionable, to a whole genome world where there will be more strong and clinically valid associations," says Greely.
However, HDRS might not at all be a clinically relevant outcome and other more clinically relevant outcomes might be more valid to use in future trials.
Other complaints may be more valid.
It shouldn't be more valid, because you're popular.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com