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Drugs that result in forms of NF-κB that repress anti-apoptotic gene expression might be more clinically effective.
Several authors have independently reported that inclusion of HPV assessment in screening for cervical cancer may be more clinically effective than Pap tests alone at higher but still 'reasonable costs' (Goldie et al, 2001; Kim et al, 2002; Mandelblatt et al, 2002).
Subsequently, a phase I trial demonstrated that 10,000 30,000 but not 100,000 units ingested IFN-α act as a biological response modifier without apparent toxicity in humans with multiple sclerosis (15), and a phase II trial suggested that 10,000 units may be more clinically effective than 30,000 units (16).
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Due to the broad effects of hypothermia, it is more clinically effective than treatments that focus on blocking just one of these processes.
The study also proved that caseload midwifery is more clinically effective.
Conclusion: First-trimester screening for Down syndrome with nuchal translucency screening alone or with serum markers is more clinically effective and cost-effective than the current expanded AFP screen that is being used.
However, it remains unclear which of these inhibitor types is more clinically effective.
More rigorous comparison may be needed to differentiate the effects caused by higher dose RT versus lower dose RT, and whether long-course fractionated RT or hypofractionated RT is more clinically effective.
More studies are needed to determine whether antimicrobial agents with in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA) are more clinically effective than those lacking such activity.
On the basis of the present evidence it therefore cannot be concluded definitively that biologics are more clinically effective than synthetic DMARDs, although a radiological difference in favour of biologics is plausible.
Accordingly, MRI results in significant treatment cost benefits that are very likely to offset the costs of the procedure itself as well as being more clinically effective than the alternatives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com