Although liposome entrapment of antibiotics and their increased efficacy is not a novel finding, neutral liposome-entrapped antibiotics tended to be more bactericidal in sputum and in the presence of sputum components when compared to free antibiotics, but with reduced efficacies over a longer period of time in vitro (18 h exposure).
Whether or not pulsed UV light was more bactericidal than continuous UV was still debated.
The lead compound, HT61 which is a topical antibiotic, is more bactericidal for non-multiplying bacteria than marketed antibiotics but is less potent against multiplying organisms.
TauCl2 is more bactericidal than TauCl, especially against Gram-negative bacteria, probably due to better penetration into bacteria.
Our results for the first time demonstrated that the in vitro bactericidal activity of Gnps conjugated ampicillin, streptomycin and kanamycin were more efficient compared to their respective free forms.
In a model of L. meningitis infection, an ampicillin-gentamicin combination (in vitro synergy) turned out to be more rapidly bactericidal than either when used alone [ 22].
Interestingly, the combination of COL + VAN resulted to be more rapidly bactericidal than both COL + MEM and COL + VAN + MEM combinations.
All the remaining triplet and quartet combinations were bactericidal compared to the results for the untreated controls (Fig. 2), thus translating successfully from in vitro bactericidal effect to in vivo bactericidal effect.
In our study, S. mutans growing in a fibrinogen-induced biofilm was found to be more resistant to the bactericidal activity of penicillin.
In case of P. aeruginosa, AfAg-NPs was found more potently bactericidal than EnAg-NPs, while against S. aureus, EnAg-NPs was more effectively bactericidal than AfAg-NPs.
