Furthermore, the ability to reduce the volume of normal lung receiving low doses was limited, because the intensity of the static beams could not be modulated to achieve good target conformity.
This technology has facilitated the identification of 'novel, druggable targets' that can be modulated to control or cure cancer.
As such, ligand binding to one protomer can be modulated by targeting a binding site within the second, interacting protomer.
The activity of cdks can be modulated by targeting these kinases with small molecules that bind to the ATP binding pocket of cdks, or by altering the composition of the cdk/endogenous cdk inhibitor complexes by different mechanisms.
This has important implications because it indicates that the amplitude of overt rhythms may be modulated by targeting the SCN shell specifically.
Our data suggest that transcriptionally mediated alterations in Angpt1, Tek, and Kdr during sepsis may potentially be modulated through targeting histone acetylases/deacetylases.
The present data add to growing evidence that impulsive responding on the 5-CSRTT can be modulated by interventions targeting the NAcbC.
Looking at differences in expression between BaP-treated and control mice as a ratio and pooling according to target status, we found eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) to be modulated significantly differently between target and non-target tissue (p < 0.05; Figure 4).
Our data also suggested that miRNA-mediated regulation can be modulated on specific target mRNAs through the poly(A) tail control.
