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The use of microarray-based gene expression analysis can provide better insights of the underlying mechanisms involved in As-induced diseases and could help to identify target genes that can be modulated to prevent disease.
VEGF splicing is regulated by the SR protein kinase SRPK1 (Nowak et al, 2010), and it has been shown that in a carcinoma cell line (LS174t) the splicing of VEGF can be modulated to prevent the production of pro-angiogenic isoforms through the lentiviral knockdown of SRPK1.
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The torque output of an engine is modulated to prevent the wheel spin caused by rapid increases in the throttle input.
Once a cell has been severely injured, necrosis is difficult to prevent whilst the apoptotic pathway can be modulated to maintain cell viability [12].
Once a cell has been severely injured, necrosis is difficult to prevent whilst the apoptotic pathway can be modulated to maintain cell viability [ 12].
Remarkably, MHC I suppression in CTVT is not complete and, in fact, is modulated presumably to prevent recognition and killing by NK (natural killer) cells [ 4].
Our work provides a new perspective for understanding how evolution might result, for functional reasons, in regions characterized by a significant fibrillogenic tendency, and suggests a protection mechanism through which aggregation can be modulated or even prevented.
"You'd expect clouds to be modulated in the same way," Dr. Sloan said.
The postsynaptic Ca2+ transient can be modulated by inhibition of Ca2+-activated phospholipid-dependent protein kinase C (PKC) activity to prevent AMPA receptor-mediated synaptic depolarization [ 19, 73].
Individual cases should be evaluated and the ambition to be the decisive force everywhere in the world should be modulated.
In healthy individuals, the efflux of cholesterol from the arterial intima is modulated by HDL and prevents lipid oxidation.
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