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Thus, our manuscript is the first causal in vivo demonstration of how T cell/dendritic cell interactions can be modulated to determine T cell phenotype in a way directly relevant to human and animal health (as stated by Reviewer 2).
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Moving forward, it will be important to develop experimental models in which the levels of oxidative stress and the activities of sirtuins can be precisely modulated to determine if sirtuins have a causative role in lifespan extension.
Various conditions in which other cell survival pathways are modulated may determine whether FTIs have a cytotoxic or proapoptotic effect.
To determine whether PEDF could be modulated by the noncanonical pathway, Wnt5a was added to HepG2 cells with and without LRP6.
It is therefore important to understand the pathways that regulate the SASP, to determine how it can be modulated and whether the potentially deleterious effects of the SASP can be inhibited without sacrificing the beneficial effects of senescence.
Schmahmann [ 45] theorizes a universal cerebellar transform, which facilitates automatic modulation of behavior around a homeostatic baseline, where the behavior being modulated is determined by the specificity of anatomic subcircuits within the cerebrocerebellar system.
MMPs can either actively modulate or be modulated by the molecular mechanisms that determine the debris-induced remodeling of the periprosthetic microenvironment (summarized in Figure 2).
MMPs can either actively modulate or be modulated by the molecular mechanisms that determine the debris-induced remodeling of the periprosthetic microenvironment.
Context can be kept constant in a trial to determine efficacy and can be modulated through a variety of factors in the clinical setting, such as the belief of providers and patients [ 28], attitude and demeanor of the doctor [ 29, 30], enthusiasm for the delivery of the intervention [ 31, 32], cultural contexts and concomitant suggestions regarding diet and health [ 33, 34].
To determine whether blood leukocyte populations could be modulated in endometriosis.
In either event, host pulmonary inflammatory responses may be modulated by HIV and potentially by genetically determined immunologic responses.
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CEO of Professional Science Editing for Scientists @ prosciediting.com