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Since only a few genes, i.e. Timps, Mmps, procollagens and stathmin, turned out to be modulated in both GN-11 cells and MEFs.
The observations that both IL-6 and claudin 2 may be modulated in both human and murine inflammatory disease of the intestine suggest that this relationship could be of importance in the pathogenesis of inflammatory bowel disease.
The molecular constituents of spines, and the associated dendritic length/branching to a lesser extent, may promote functional plasticity and/or be modulated in both normal and pathological aging.
These observations are consistent with findings of Schrader [ 22], suggesting that auxin responses may be modulated in both cambial meristem and adventitious buds during endodormancy, and Li [ 49] that indicated auxin levels were reduced in terminals buds of silver birch (Betula pendula) during short-day-induced dormancy.
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In a more recent work, Triki [113] verified that, in acoustic signals, each harmonic partial is modulated in both amplitude and frequency.
In addition, the analysis of genes associated with nutrient metabolism indicated that fatty acid and starch metabolism was modulated in both wild and cultivated rice in response to the pathogen.
The expression levels of miR-24 in WI-38 cells were modulated in both directions, elevated by using a pre-miR-24 RNA, reduced by using an antisense (AS -miR-24 RNAS -miR-24
In contrast, the number of genes modulated by Chk1 inhibition was significantly higher among tetraploid (152 genes) than among diploid cells (20 genes), with only six genes that were modulated in both diploid and tetraploid cells (Fig. 7A,B), again correlating with the enhanced killing of tetraploid cells by Chk1 inhibitors.
To test the hypothesis that cytokine signal transduction is modulated in both pathway- and cell-specific manners that correlate with SLE disease status, we analyzed samples collected before disease onset through initiation to the terminally severe phase using the MRL/lpr murine model of SLE.
Only 184 genes were modulated in both groups (Table 1).
(3) Concordant genes which were modulated in both disease stages.
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