Sentence examples for be modulated by targeted from inspiring English sources

Our results provide detailed insights into the catalytic and non-catalytic processing of small molecules by hCE1, and suggest that the efficacy of clinical drugs may be modulated by targeted hCE1 inhibitors.

This study identified specific and prioritized sets of key nodes in hepatic molecular networks underlying T2DM, uncovering pathways that are to be modulated by targeted T2DM drug interventions in order to modulate the complex disease phenotype.

Apoptosis can be modulated by targeting pro-apoptotic or pro-survival pathways.

The activity of cdks can be modulated by targeting these kinases with small molecules that bind to the ATP binding pocket of cdks, or by altering the composition of the cdk/endogenous cdk inhibitor complexes by different mechanisms.

As such, ligand binding to one protomer can be modulated by targeting a binding site within the second, interacting protomer.

This has important implications because it indicates that the amplitude of overt rhythms may be modulated by targeting the SCN shell specifically.

Second the set-size effect is modulated by target-distractor similarity.

While pain control and epilepsy are still the major focus of interest in terms of sodium channel drug development, it remains possible that indications ranging from autism to immune disorders may be modulated by compounds targeted at sodium channel activity.

The present data add to growing evidence that impulsive responding on the 5-CSRTT can be modulated by interventions targeting the NAcbC.

It appears that individual serpins may inhibit proteinases in different proteolytic cascades; while particular physiological responses might be modulated by serpins targeting different steps in the same proteinase cascade.

These results show AAV receptor interactions can be modulated by a target protease.