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It is known that chemokine responsiveness in neutrophils can be modulated by some inflammatory conditions, such as sepsis.
The homeostasis of intracellular Ca2+ level ([Ca2+]i), which could be modulated by some ER localized proteins, is important for osteoblast differentiation.
Although vitamin D metabolism might be modulated by some dietary factors, particularly intake levels of calcium, 20 retinol 21, and alcohol, 22 23 the potential interactions have not been well studied in previous considerations of the vitamin D-colorectal cancer hypothesis.
Our previous study showed that the amount of NO released from irradiated tumour cells was related to the dose and LET of irradiation, and suggested that radiation-induced NO might be modulated by some unknown factors during cell-programmed death (Shao et al, 2001).
If the breast cancer incidence among Ashkenazi women in Brazil, which was not evaluated in this study, has been showing a similar pattern to breast cancer mortality, a hypothesis can be raised that germ mutations previously reported among Ashkenazi women may be modulated by some environmental factors that perhaps could act as protective factors, delaying the mutation expression.
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There is, however, evidence that native insect GABAA receptors are modulated by some benzodiazepines.
It may indicate that the transcription process in the stationary phase is modulated by some global regulator, like an alternative sigma factor.
In the present work we checked whether two polymorphisms, c.-61G>T and c.-98G>C, of the RAD51 gene were associated with KC/FECD occurrence and whether this association was modulated by some demographic and potential risk factors for KC/FECD.
Next, we evaluated the DNA methylation status of the genes for RRM2, TOP2B and TOP2A in order to determine whether the differently observed mRNA expressions were modulated by some epigenetic modification inherent to drug-resistant AML cells.
For example, a recent study demonstrated the enhancement of ribosomal subunit translation and ribosome biogenesis upon miR-10a binding via a "non-seed" site at the transcript 5' UTR [ 5] and confirmed that ribosome formation can be modulated by miRNA to some extent.
Taken together, these studies indicate that the uptake of ReA-triggering bacteria might be modulated by HLA-B27 in some cell types with certain experimental systems.
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