Sentence examples for be modulated by small from inspiring English sources
Interaction of HER2 protein with other EGFR proteins can be modulated by small molecule ligands and, hence, these protein protein interactions play a key role in biochemical reactions related to control of cell growth.
Syntaxin activity was also recently shown to be modulated by small GTPases of the Rab sub-family, namely Rab11 [ 23].
This in turn provides a broad range of transcripts and pathways that could potentially be modulated by small RNAs, perhaps including siRNAs that function as microRNAs.
Using a chemical genetics approach, we have asked whether this control network can be modulated by small molecules such that p27 protein expression is restored in cancer cells.
Given that the activity of TLR7 and 8 can be modulated by small synthetic agents such as mianserin, these receptors may provide amenable targets for the development of new therapeutics for RA.
Their importance in metabolism, combined with their ability to be modulated by small lipophilic ligands, make NHRs one of the most highly therapeutically targeted protein families, serving as targets for drugs including glucocorticoids, thyroid hormone, tamoxifen, fibrates and TZDs.
The function of the SMO receptor can be modulated by small-molecule agonists and antagonists, some of which are potential antitumour agents.
Their activities are modulated by small hydrophobic compounds, such as steroids, fatty acids, retinoids and thyroid hormones.
First, GPCRs locate on the plasma membrane and their functions are modulated by extracellular molecules, placing them among the most druggable targets: highly accessible to drugs and the functions are modulated by small molecules.
It has been described in the literature that the properties of actin are modulated by small heat-shock proteins including a direct actin-small heat-shock protein interaction to inhibit actin polymerization to protect the cytoskeleton [ 40, 41] (compare with the CLANS cluster 24 (Diapause proteins) found in the above analysis).
Importantly, these are candidate mediators in a therapeutic setting since both AR's binding and transcriptional activities at these loci were modulated by small-molecule antagonists.
