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The response to the neurotransmitter binding can be modulated by several chemical compounds acting at topographically distinct sites, as documented by a large body of literature.
Importantly, the developmental trajectory of brain changes is not uniform and may be modulated by several factors such as onset of disease mechanisms, risk-associated and protective genes, converging comorbidity, and individual brain reserve.
This proteolytic activity of the aggrecanases can be modulated by several means, including altered expression, activation by proteolytic cleavage at a furin-sensitive site, binding to the aggrecan substrate through the C-terminal thrombospondin motif, activation through post-translational processing of a portion of the C-terminus and inhibition of activity by the endogenous inhibitor TIMP-3.
Inflammatory responses may be modulated by several anti-inflammatory or otherwise immunomodulatory cytokines.
ER regulation is not limited to direct ligand binding, because it can also be modulated by several other pathways.
The risk of sporadic colorectal cancer is mainly associated with lifestyle factors and may be modulated by several genetic factors of low penetrance.
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Because Ehd1 is modulated by several regulators, it acts as a mediator of various floral signals.
Stem cell differentiation is modulated by several key molecules, including cytokines, hormones, and engineered peptides.
These main effects were modulated by several interactions.
Moreover, we could demonstrate that sustained regulation is modulated by several factors.
Although Ddc activity is modulated by several factors [54] [56], little is known about its gene regulation.
More suggestions(17)
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